About the ACMG Evidence-Based Guidelines Program


The Evidence-Based Guidelines (EBG) Program develops professional practice guidelines in medical genetics and genomics informed by a systematic review of evidence that evaluates the clinical utility of genetic or genomic services. ACMG’s guidelines help clinicians make informed decisions regarding the use of genetic and genomic testing and aid both government and private health insurers in determining coverage options for new tests and treatments.

The ACMG Foundation is working to build support for this critical program. With your help, ACMG will develop, publish, and regularly update evidence-based guidelines. The support of individuals, foundations, and corporate donors will ensure that ACMG can disseminate guidelines more often and more quickly, now and in the future.

  • A 2019 press release announcing the launch of the EBG Program can be found here .
  • Please click here  to read the one-page overview of the EBG Program. This is perhaps the best entry point to the effort.
  • The ACMG Board and staff developed a Protocol Manual for the EBG program in 2014, revised it again in 2019 as they launched the full EBG Program, and again updated the document in 2022 to reflect the growth of the program, which can be found here . The manual guides the ACMG Board and committee members in the development of EBGs.

The development of each new guideline will demand a tremendous investment of staff time at every level of the organization. Two areas will be crucial for the successful management of this program:

  • A dedicated EBG Fund for donations from all sources that includes a firewall between the fundraising teams on the side of the ACMG Foundation and the scientific teams working under the banner of the ACMG. Documents that outline the ACMG Foundation’s “Guidelines Fund” can be found here .
  • A carefully managed budget will ensure that resources raised for this effort will be directed towards the proper resources to ensure a successful effort each time a new guideline is published. To review some sample budgets that the ACMG Foundation drafted as goals for both the overall program and for fundraising targets, please click this link .

More Information

For questions related to the Evidence-Based Guidelines Program, please contact the ACMG Foundation at acmgf@acmgfoundation.org .